Protein

Protein accession
A0A345ANS5 [UniProt]
Representative
2cctI
Source
UniProt (cluster: phalp2_39083)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MSVTRTRTIIAALTVSAAAFGAWQVREGYTDHAVIPTKGDVPTIGHGSTRYEDGTPVKMGDTITRRRAAELARNLMAKDEKDFRASLPPDTKLAQAEYDEYVDFIGQFGIGNWRKSTMRREIISGDYAAACKGLLNYRFAAGYDCSTLVDGRPNKRCYGVWVRQQKRYANCMGAR
Physico‐chemical
properties
protein length:175 AA
molecular weight:19512,9 Da
isoelectric point:9,45
hydropathy:-0,49
Representative Protein Details
Accession
2cctI
Protein name
2cctI
Sequence length
254 AA
Molecular weight
27860,56870 Da
Isoelectric point
9,81862
Sequence
MGTREVAVEAAKATPPAAVVAANKVMGLDLPTIVALVTLLYLLIQIGHLLWKWRNEATDRRKRNLYVERDRRRQRGAADRVLVSALALSLAGFAAWMASEGSSPAVVVSGETRLAPHIPTAGDVPTIGHGATHYEDGRPVRLTDPPISQARAETLARNLLSEDERRFKASLPGVALHQAEYDLYVDFVGQYGIGTWNKSSMRRALLAGNHPAACNALLRYRYAAGYDCSTPGNRRCAGVWARQQARHKRCLEVQ
Other Proteins in cluster: phalp2_39083
Total (incl. this protein): 5 Avg length: 191,2 Avg pI: 9,41
Protein ID Length (AA) pI
2cctI 254 9,81862
A0A6M5CBT5 181 9,65783
A0A345BQX2 177 9,13506
A0A345MKX1 169 8,96099
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_33447
7bNjX
 23 61,7% 188 9.473E-82
2 phalp2_15849
4kKIv
 1444 55,1% 176 5.832E-68
3 phalp2_8252
7B99h
 46 31,5% 190 1.994E-11
4 phalp2_26423
1LaGk
 3 29,7% 175 6.526E-11

Domains

Domains [InterPro]
Disordered region
Unannotated
GH24
Representative sequence (used for alignment): 2cctI (254 AA)
Member sequence: A0A345ANS5 (175 AA)
1 254 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Ralstonia phage phiRSP
[NCBI] 		2201420 Coatlandelriovirus > Coatlandelriovirus RSP
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MH252365 [NCBI]
CDS location
range 16453 -> 16980
strand +
CDS
ATGAGCGTCACGCGCACCCGCACCATCATCGCCGCGCTGACTGTCAGCGCCGCAGCATTCGGTGCGTGGCAAGTCCGCGAGGGATACACGGACCACGCAGTGATCCCCACGAAGGGCGATGTGCCCACCATCGGCCACGGTTCGACGCGCTACGAAGACGGCACGCCCGTGAAGATGGGCGACACCATCACACGCAGGCGCGCCGCTGAACTGGCGCGCAATCTCATGGCGAAGGACGAAAAGGATTTTCGTGCATCGCTGCCGCCGGACACGAAGCTGGCCCAAGCCGAGTATGACGAATACGTGGACTTCATCGGGCAGTTCGGCATCGGCAACTGGCGCAAGTCCACGATGCGCCGCGAAATCATTTCCGGCGACTACGCGGCAGCCTGCAAGGGGTTGCTGAACTATCGCTTCGCGGCAGGCTATGACTGCAGCACGCTGGTGGACGGCCGGCCGAACAAGCGCTGCTATGGCGTGTGGGTGCGCCAGCAGAAGCGCTATGCAAACTGCATGGGGGCGCGATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

PDB ID
A0A345ANS5
Method AlphaFoldv2
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (2cctI) rather than this protein.
PDB ID
2cctI
Method AlphaFoldv2
Resolution 90.29
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50