Protein

Protein accession
A0A386K889 [UniProt]
Representative
2YSsA
Source
UniProt (cluster: phalp2_24237)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MARVQFKQRESTDAIFVHCSATKPSQNVGVREIRQWHKEQGWLDVGYHFIIKRDGTVEEGRDEMAVGSHAKGHNHNSIGVCLVGGIDDKGKFDANFTPAQMQSLRSLLVTLLAKYEGAVLRAHHDVAPKACPSFDLKRWWEKNELVTSDRG
Physico‐chemical
properties
protein length:151 AA
molecular weight:16997,0 Da
isoelectric point:8,47
hydropathy:-0,53
Representative Protein Details
Accession
2YSsA
Protein name
2YSsA
Sequence length
224 AA
Molecular weight
25533,28830 Da
Isoelectric point
9,28263
Sequence
MPWLRRLPHSTMWMQMDWPWHSVRQRCKKARLAKPSERGLISEHPLPEAIRVFYSEATMQITACPIALPLGKLSALAGVKFIAVHCSATRPTALMGVRDIHRMHIERGFACIGYHYVIKRDGTIERGRPEDKMGAHVEGHNRDSLGVCLIGGIDADGKAKNNFTQDQFDSLKSLLLSLHGKYPKAVIQGHRDFFGDTNKDGKIDSRDWLKECPCFDVKTWWEQK
Other Proteins in cluster: phalp2_24237
Total (incl. this protein): 71 Avg length: 156,6 Avg pI: 8,16
Protein ID Length (AA) pI
2YSsA 224 9,28263
14Sf5 167 8,94262
1IIPY 166 9,05196
1JLLv 167 8,97002
1LgWS 167 9,09644
1LpdF 167 9,03848
1MkSn 167 8,92966
1cWRh 167 8,92966
1qtvY 169 8,91748
2RUcQ 167 8,75282
36CUz 167 8,91722
4fPHV 167 8,92998
4fSDR 167 8,92979
4g2oD 167 8,94249
4g4Dy 167 8,91735
4gB4r 169 8,91748
4gSCJ 169 8,74290
86PvK 166 8,89272
8dJDh 167 8,90523
8dpdq 167 8,95609
8reFw 169 8,95622
eMni 169 8,53221
lL0p 167 8,98491
B3VD45 151 9,05086
A0A2P0ZKF3 144 7,78747
I6Q8U0 151 8,80846
A0A2S1GSX4 149 8,46884
Q4TVX2 144 7,80108
A0A4Y5TV11 164 6,43187
A0A1B0Z0F0 164 6,05161
A0A2D0XQH4 144 7,78747
A0A2D0YKS4 144 7,78747
A0A2D0YKY3 144 7,78747
A0A2D0YL19 144 7,78747
A0A2D0YM49 144 7,78747
A0A2D0Z118 144 7,78747
A0A2D0Z1S4 144 7,78747
A0A2D0Z257 144 7,78747
A0A2D0Z2G5 144 7,78747
A0A2D0Z5R8 144 7,78747
A0A2D0Z6V4 144 7,78747
A0A2I7R4X9 142 6,69418
A0A2I7RP54 142 6,69418
A0A2I7RVA7 139 8,58953
A0A2I7S8S6 142 6,69418
A0A2Z5HC51 151 8,82606
A0A5B9C1V6 164 6,69986
A0A6B7SEH7 153 7,67732
A0A6B9J013 153 6,99446
A0A6G9L9I1 153 7,67704
A0A6M3TA00 153 7,67704
A0A6M5CCW8 151 7,78786
A0A7G9UTP8 151 8,46723
A0A7T7GRY3 164 6,05724
F1D074 144 7,78747
F1D0C2 144 7,78747
F1D0L7 144 7,05141
A0A8X8M5C7 151 8,47026
A0A8X8M5V4 151 8,47026
A0AA51Z351 151 9,05131
A0AAD2GQQ7 151 9,07433
A0AAE8B0K0 151 8,82548
A0AAX3DFK1 151 8,79176
A0A9P0VJK1 177 6,23907
A0A9P0YAK5 177 6,34809
A0AAE9ST54 153 5,78498
A0AAF0GJA0 155 8,37478
A0AAU8ED42 151 8,82625
A0AAX4GJ75 151 8,82625
A0AAX4GS35 151 8,82625
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_28564
7Z48s
 97 48,9% 145 3.182E-65
2 phalp2_3887
6RreM
 7260 53,1% 143 2.144E-58
3 phalp2_36193
72BPm
 409 51,7% 143 3.275E-56
4 phalp2_11894
2jrH4
 329 47,6% 149 1.038E-54
5 phalp2_12381
8yxE3
 11 44,7% 143 3.654E-51
6 phalp2_5171
285Oe
 13 48,9% 143 5.002E-51
7 phalp2_11611
1k5JO
 2203 45,3% 141 6.827E-48
8 phalp2_2237
4n15b
 512 45,9% 148 3.248E-44
9 phalp2_23766
13ajC
 287 43,6% 158 6.686E-42
10 phalp2_28171
8yYQh
 287 39,3% 155 8.190E-41

Domains

Domains [InterPro]
Disordered region
Ami2
Representative sequence (used for alignment): 2YSsA (224 AA)
Member sequence: A0A386K889 (151 AA)
1 224 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Escherichia phage C5
[NCBI] 		2340717 Autographiviridae > Teseptimavirus > Teseptimavirus C5
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MH717099 [NCBI]
CDS location
range 10303 -> 10758
strand +
CDS
ATGGCTCGTGTACAGTTTAAACAACGTGAATCTACTGACGCAATCTTTGTTCATTGCTCGGCTACCAAGCCAAGTCAGAATGTAGGTGTCCGTGAGATTCGCCAGTGGCATAAAGAGCAAGGTTGGCTTGATGTCGGGTATCACTTTATCATCAAGCGCGATGGCACAGTAGAGGAAGGTCGAGATGAGATGGCTGTAGGCTCTCACGCTAAGGGTCACAACCACAACTCTATTGGTGTCTGCCTTGTAGGTGGTATCGACGATAAAGGCAAGTTTGACGCTAACTTTACGCCAGCCCAAATGCAATCCCTCCGCTCACTGCTTGTCACACTGCTGGCTAAGTACGAAGGCGCTGTGCTTCGCGCACATCACGATGTGGCACCTAAGGCTTGCCCATCGTTCGACCTTAAGCGTTGGTGGGAGAAGAACGAACTGGTCACTTCTGACCGTGGATAA

Gene Ontology

Description Category Evidence (source)
GO:0008270 zinc ion binding molecular function None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0032897 negative regulation of viral transcription biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.5.1.28 None Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		HAMAP-Rule:MF_04111

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (2YSsA) rather than this protein.
PDB ID
2YSsA
Method AlphaFoldv2
Resolution 77.82
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50