Protein

Protein accession
A0A2H4PIY8 [UniProt]
Representative
725I0
Source
UniProt (cluster: phalp2_28047)
Protein name
Lysin A
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MATMPVDKGFYVTSPYAERWGTFHWGTDFGLDGGSGGHPIYAVKYGTVTAAGAASGFGQWINLDHPAGNGGGLSVYGHIIPEVSVGQTVVEGQRIGYINPNSSTNGGVAPHLHYEYHRYVWSPPGADRLDPESTVLAGAHWPGDARSFDVDTLGDLMGWTLTRERYAELYPAYVKMLQIIGASSVNAHAMVGAQLGHESVGLKYQEEIASGSAYEWRSDLGNTQSGDGTRFKGHGWIQVTGRANHLAVSQWAYARGIVPSSTYFVDNPAQLGNDQYCWVGPAWYLTAARSGFLAAADRGELESCTRMINGGLNGIDDRRARYNRALTLGARLIPNQDGGFLMALSDDEQRELLDKTRRIHHELTHEFQSLYTDKDGNRSTWRGTMMGYLLQLDRKVENVHQFLLPEVLTTIQVLVKKDKTKGDNDNEQ
Physico‐chemical
properties
protein length:428 AA
molecular weight:47072,8 Da
isoelectric point:5,88
hydropathy:-0,44
Representative Protein Details
Accession
725I0
Protein name
725I0
Sequence length
455 AA
Molecular weight
49597,97270 Da
Isoelectric point
9,52599
Sequence
MDARTLSEAMGGSLSLARYKELLPAYEKMLRIIGADTVRKCAMVAAQLGHESVGLKYQEEIADGSAYEWRADLGNTQPGDGRRFKGHGWIQITGRHNHTAVSKWAHQRGIVPVADYFVRNPKALGSDQYCWIGPAWYLTAARPGFMAMAERGDLEGCTRAINGGLNGLSDRRARYNRALTLGTRLLPGGAVAKIEKRLDYPRAIVKQDTSYWCGPATGQMLMAARTGKVVPESTLASEMGTTINGTNGVGQIARVLNQRMPGAGWTVVDMPNDPPSKAQKDLLWEHLTQSIDAGVGIAANIWAPVNNYPRASYTSTQNLRYSGGFVRHYVALMGYAVDSNGTRHVWWADSGFAPFGSWVTFDQTASLIPPRSYAYAHGIVAAHKAKTTTIDWTPHAMNLLKEIWTQLRGPGGKGWLQLGKNAKGQNLSLVDGVAACRADIAALTKKIDDLKEGLK
Other Proteins in cluster: phalp2_28047
Total (incl. this protein): 68 Avg length: 466,8 Avg pI: 5,81
Protein ID Length (AA) pI
725I0 455 9,52599
11sRZ 467 4,98878
11wha 468 4,91756
13puD 461 5,03539
13puZ 478 5,04625
1cwRC 483 5,20960
1cxam 463 4,88613
1emm3 466 8,54150
1jU4Q 469 4,97684
1kk89 464 5,11212
1klZ6 475 4,93950
2lQhY 463 6,20718
3ceMc 480 4,88516
3kVXT 471 5,10365
5FgjZ 466 6,42533
5GbhR 481 4,83259
5ICaf 460 5,82852
5PKBI 463 4,80945
61iV9 463 4,80701
6Yzlz 474 4,96781
6ZGaP 463 4,81309
6ZOMf 469 5,01237
6ZbTE 469 4,95547
6ZfvQ 496 5,02567
6acie 480 4,93979
6h3X6 483 5,01487
6nkPX 469 5,06142
6otua 480 4,96798
6r1hF 456 4,76029
6wgiz 480 4,96030
70k3g 469 5,07358
711DC 480 5,02391
7ABlf 481 5,82869
7AevZ 481 5,58070
7Aexx 481 5,41462
7Aez3 481 5,66539
7C1pN 445 8,64587
7NGX2 463 4,84725
7Nu7H 480 5,07677
7O34v 467 5,05523
7OOsn 469 5,06250
7gDgo 442 9,27437
7h6IJ 463 7,06619
7hw2V 463 6,47762
7s0xr 472 9,68646
7ubtZ 453 5,60503
7uhyx 417 6,20957
87yix 480 5,01106
8Ilxc 502 7,61804
8Ilxd 479 6,44630
8LCot 481 5,58684
8LLeG 486 6,14062
8MIIt 486 9,07304
8hhUU 480 4,92745
8ouRC 480 4,97343
8r3mU 480 5,02345
HBCp 472 4,92012
MW5F 474 5,01862
p2pm 469 5,30066
pnxt 463 4,84396
ug2O 471 9,46862
x1Di 465 4,64502
yslL 469 5,00731
z4jG 469 4,99532
A0A2H4PIV9 426 6,01001
A0A514DKF1 486 9,07304
A0A9E8M8Z6 273 8,81845
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_36873
7ptMs
 9 53,1% 284 4.771E-149
2 phalp2_3109
42vZA
 6 39,0% 443 2.773E-138

Domains

Domains [InterPro]
Unannotated
PET_C39
Unannotated
Representative sequence (used for alignment): 725I0 (455 AA)
Member sequence: A0A2H4PIY8 (428 AA)
1 455 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF13529

Taxonomy

  Name Taxonomy ID Lineage
Phage Corynebacterium phage phi674
[NCBI] 		2052822 Ikedavirus > Ikedavirus phi674
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MG324354 [NCBI]
CDS location
range 20634 -> 21920
strand +
CDS
ATGGCAACGATGCCAGTAGATAAAGGTTTCTATGTCACATCCCCATATGCTGAGCGCTGGGGCACGTTCCACTGGGGTACTGATTTTGGATTAGATGGTGGATCTGGTGGGCATCCCATCTATGCCGTCAAATATGGCACTGTCACTGCAGCAGGTGCAGCCAGTGGTTTTGGTCAATGGATCAACCTGGATCACCCTGCTGGTAATGGTGGTGGTCTCTCAGTCTATGGCCACATCATTCCAGAGGTCAGCGTAGGTCAGACAGTGGTGGAGGGGCAGCGCATTGGGTATATTAACCCCAATTCTTCCACCAATGGAGGTGTGGCACCTCACCTGCACTATGAGTATCACAGGTATGTGTGGTCTCCACCTGGAGCTGATCGTCTAGATCCAGAGAGCACAGTACTTGCTGGTGCTCATTGGCCTGGAGATGCCAGATCATTTGATGTGGACACTCTAGGGGATCTCATGGGGTGGACACTAACACGTGAGCGCTACGCAGAGCTGTACCCAGCGTATGTGAAGATGCTGCAGATCATTGGTGCATCTAGTGTCAATGCACATGCCATGGTGGGTGCACAGCTGGGGCATGAGTCAGTGGGTCTGAAATACCAGGAAGAAATAGCCTCTGGCAGTGCCTATGAGTGGAGATCTGATCTGGGCAATACTCAATCTGGAGACGGTACCCGATTCAAGGGGCACGGGTGGATTCAGGTCACAGGACGTGCCAACCACCTGGCTGTATCTCAGTGGGCATATGCCAGAGGTATTGTGCCCAGCTCTACCTACTTTGTGGATAACCCAGCACAGCTGGGCAATGATCAGTATTGCTGGGTGGGGCCTGCCTGGTACCTCACTGCAGCACGTAGTGGTTTCCTGGCTGCAGCTGATCGTGGAGAGCTGGAGAGCTGCACCCGCATGATTAATGGGGGTCTCAATGGCATTGATGATCGCAGGGCACGTTATAACCGTGCACTCACACTGGGTGCACGTCTCATACCAAATCAAGATGGAGGTTTCCTTATGGCACTATCAGATGACGAACAGCGCGAACTACTGGATAAGACGCGCCGTATTCACCACGAACTCACTCATGAGTTCCAGTCCCTGTATACGGACAAGGACGGTAACCGCTCTACATGGCGCGGTACCATGATGGGTTACCTACTACAGCTAGACCGTAAGGTAGAGAACGTTCACCAGTTCCTACTTCCAGAGGTACTCACCACAATTCAGGTACTGGTTAAAAAGGACAAGACCAAAGGGGACAACGACAATGAGCAATAA

Gene Ontology

Description Category Evidence (source)
GO:0004222 metalloendopeptidase activity molecular function None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi000ca2e460_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (725I0) rather than this protein.
PDB ID
725I0
Method AlphaFoldv2
Resolution 93.11
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50