Protein

Protein accession
A0A1L7DQJ6 [UniProt]
Representative
6k2xA
Source
UniProt (cluster: phalp2_23419)
Protein name
Endolysin
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MSAIRQSMIYCSVAAVIGIVTTVYPNDLQTSRAGLELIASYENCVSCTYKDSIGKNTIGIGSTRGLDGKPVPNNQLLSNDDIARLLVRDIKESEECVIKYFNGQKMPQPVFDSAVSLVYNNGCYGTRWNKSANRPTFIARYAVAGDWNNVCYRFSDFVNAGGVRSKGLVNRRTAEQKLCIQYRQ
Physico‐chemical
properties
protein length:184 AA
molecular weight:20428,0 Da
isoelectric point:9,10
hydropathy:-0,25
Representative Protein Details
Accession
6k2xA
Protein name
6k2xA
Sequence length
273 AA
Molecular weight
30341,36000 Da
Isoelectric point
9,43561
Sequence
MKTSNVGIELIQKYEGCMLTAYRCPAGVLTIGYGHTGKVDGQEIYRGMKITKAKAIELLKSDLSKFEKHVMKYDSIYHYNQNQFDALVSFSFNIGRIDQLTANGTRSISQISSKIPAYNKAGGKVLAGLVKRRNEEKLLFDSSISITTQETSVGTTYTVVNGDTLSGIGHKVGMNWRKIAEINSIQSPYTIHPGQVLKLTETTANNNGSKFPYKIIVATEKDNLNVRSGPGLNYKKVKSLKKGSENSIIEEENGWGRLEDKSGWVCLEYIKRI
Other Proteins in cluster: phalp2_23419
Total (incl. this protein): 3 Avg length: 213,7 Avg pI: 9,21
Protein ID Length (AA) pI
6k2xA 273 9,43561
I7K3G5 184 9,09592
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_10187
xiY3
 70 51,1% 180 1.169E-39
2 phalp2_34008
81fvs
 10 44,2% 183 1.595E-39
3 phalp2_28113
7zmZV
 50 45,5% 193 7.272E-34
4 phalp2_40316
3fQk2
 50 37,1% 277 1.840E-33
5 phalp2_14481
4Lj5N
 23 34,2% 216 1.419E-23
6 phalp2_24849
7vCQq
 8 36,4% 203 2.211E-22
7 phalp2_20210
8eGjW
 19 33,6% 214 1.809E-16
8 phalp2_19412
2Foe6
 6 33,1% 208 2.441E-16
9 phalp2_38353
ATmM
 19 29,3% 184 1.090E-11
10 phalp2_19992
6T980
 5 33,8% 183 1.090E-11

Domains

Domains [InterPro]
GH24
LysM
SH3_3
Representative sequence (used for alignment): 6k2xA (273 AA)
Member sequence: A0A1L7DQJ6 (184 AA)
1 273 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959, PF01476, PF08239

Taxonomy

  Name Taxonomy ID Lineage
Phage Yersinia phage fHe-Yen3-01
[NCBI] 		1932893 Autographiviridae > Pokrovskaiavirus > Pokrovskaiavirus fHeYen301
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
KY318515 [NCBI]
CDS location
range 41248 -> 41802
strand +
CDS
ATGAGTGCTATCAGACAGTCGATGATTTATTGTAGCGTAGCAGCCGTTATAGGCATTGTTACGACCGTTTATCCCAATGACCTTCAAACATCAAGAGCAGGTCTTGAGCTTATAGCAAGTTATGAGAATTGTGTAAGCTGTACGTACAAAGACAGCATCGGTAAGAATACCATTGGAATAGGCAGTACTCGCGGCCTGGATGGTAAGCCGGTGCCAAACAACCAACTACTATCTAATGATGACATAGCCCGGTTACTGGTGCGCGACATCAAAGAATCTGAAGAATGTGTAATCAAGTACTTTAATGGCCAGAAGATGCCACAGCCGGTATTTGATAGTGCGGTTTCGTTAGTGTACAACAATGGCTGCTATGGCACCCGTTGGAACAAGAGTGCCAATCGCCCGACATTCATTGCCAGGTATGCAGTCGCTGGTGACTGGAATAATGTATGCTACCGGTTCAGCGACTTCGTTAATGCCGGTGGTGTACGTAGTAAGGGTTTAGTTAATCGACGTACAGCGGAGCAGAAGCTATGTATACAGTACCGGCAGTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)
GO:0044659 viral release from host cell by cytolysis biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (6k2xA) rather than this protein.
PDB ID
6k2xA
Method AlphaFoldv2
Resolution 87.92
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50