Protein

Protein accession
A0A4D6ACU6 [UniProt]
Representative
7ctcW
Source
UniProt (cluster: phalp2_16536)
Protein name
Cell wall hydrolase
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MGKHLVICGHGQGRTGYDPGAVNTKLGITEAGKVRELAKIMSKYSGQQIDFITEQNVYDYRSITSIGKGYDSITELHFNAFNGSAKGTEVLIQSSLEADKEDMAILSLLSRYFQNRGIKKVDWLYNANQAASRGYTYRLVEIAFIDNEQDMAIFEKKKEDIAKGLVSAITGVEVKTIVPSPPSSTVGSSGTPSKPIYLVGDSLRVLPHATHYQTGQKIANWVKGRTYKIIQVKNVHQSNSKRAYLLDGIKSWVLEQDVVGTTKGHSEQTYQAQKGDTYYGIARKFGLTVDALLAINGLKKTDILRGGQTLKVNAASRTTTAIPTSVASRVVASALSKVGQKVTVPSNPYGGQCVALVDKIVQELTDKNMSYTNAIDCLKKAKSNGFQVIYDAWGVNPKAGDFYVIQTDGLVYGHIGVCVTDSDGKSIDGVEQNIDGYSDHNKNGINDQLEIGGGGITRRVKRQWMADGSLYDSTGTVKLGKVVGWFRIS
Physico‐chemical
properties
protein length:489 AA
molecular weight:53232,7 Da
isoelectric point:9,19
hydropathy:-0,31
Representative Protein Details
Accession
7ctcW
Protein name
7ctcW
Sequence length
329 AA
Molecular weight
35467,85690 Da
Isoelectric point
9,36456
Sequence
LREVLVSAITGVEVKTIVPSPPSSTVGSSGTPSKSIYLVGDSLRVLPHATHYQTGQKIANWVKGRTYKILQVKNVHQSNSKRAYLLDGIKSWVLEQDVEGTTKGHSEQTYQAQKGDTYYGIARKFGLTVDALLVVNGLKKSDILKVGQTLKVNAASRTTTAIPTSVASRVVASALSKVGQKVTVPSNPYGGQCVALIDKIVQELTDKNMSYTNAIDCLKKAKSNGFQVIYDAWGVNPKAGDFYVIQTDGLVYGHIGVCVTDSDGKSIDGVEQNIDGYSDHNKNGINDQLEIGGGGITRRVKRQWMADGSLYDSTGTVKLGKVVGWFRIS
Other Proteins in cluster: phalp2_16536
Total (incl. this protein): 54 Avg length: 417,5 Avg pI: 8,40
Protein ID Length (AA) pI
7ctcW 329 9,36456
75xOS 285 9,36044
A0A4D5ZY97 489 9,13486
A0A4D6AQ41 489 9,01901
A0A4D6A394 489 9,03178
A0A4D6APL7 489 8,89736
A0A1X9I678 489 8,86081
A0A7G3MLC5 489 9,14144
A0A4D6AQ16 489 9,08310
A0A4D6AMY4 489 9,08974
A0A4D6BBM2 489 9,02514
A0A4D6AP35 489 9,16252
A0A4D6A682 489 8,80930
E4ZFN7 489 9,01889
Q6DMS8 260 5,58303
A0A1B0RXF2 489 9,06369
A0A4D6A5T7 260 5,18226
A0A4D6AB55 489 8,94739
A0A4D6ALT9 285 9,33510
A0A4D6ATF3 489 8,69667
A0A4D6AV35 260 5,18226
A0A5C1K4Y0 489 9,01244
A0A7G3MID4 489 9,10327
A0A7G3MIP0 489 9,10327
A0A7G3MJ71 489 9,08310
A0A7G3MJ83 489 8,99084
A0A7G3MJY3 489 9,08967
A0A7G3MK89 489 9,06369
A0A7G3MKZ3 489 9,19546
A0A7G3ML27 285 9,33510
A0A7G3MLJ2 489 9,01237
A0A7G3MLY5 489 9,02527
A0A7G3MLY9 489 9,03178
A0A7G3MM60 489 9,14827
A0A7G3MNF8 489 9,08310
A0A7G3MNX2 489 9,15524
A0A7G3MPA4 489 9,06369
A0A7G3MPQ9 489 9,01237
A0A7G3MQL2 489 9,02527
A0A7G3MQN8 285 9,41324
A0A7G3MS80 489 8,93521
A0A7G3MTF7 342 9,48022
D0R0F0 358 9,40982
D0R0F1 121 5,17072
A0A4D6BA42 489 9,08310
A0A6M3SUI5 260 5,28127
A0A4D6A7C0 258 5,41735
A0A4D6AEM8 258 5,41735
A0A4D6AP34 468 8,99690
A0A4D6BIE7 468 8,99690
A0A6M3T9L6 258 5,41735
A0A6M9X5Z1 258 5,41735
A0A7G3MK31 134 5,58423
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_23517
71Vqv
 51 85,0% 328 1.087E-199

Domains

Domains [InterPro]
Disordered region
Unannotated
LysM
CHAP
Representative sequence (used for alignment): 7ctcW (329 AA)
Member sequence: A0A4D6ACU6 (489 AA)
1 329 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01476, PF05257

Taxonomy

  Name Taxonomy ID Lineage
Phage Streptococcus phage Javan369
[NCBI] 		2548129 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MK448741 [NCBI]
CDS location
range 33256 -> 34725
strand +
CDS
ATGGGAAAACATCTAGTCATTTGTGGTCATGGTCAAGGGCGAACAGGCTATGATCCTGGAGCTGTGAATACCAAACTAGGCATCACAGAAGCAGGAAAGGTTCGAGAATTAGCCAAGATCATGTCTAAGTACAGTGGACAACAGATTGATTTTATTACCGAACAAAATGTTTATGATTATCGGAGTATTACTAGTATTGGTAAGGGATACGACTCGATTACTGAATTGCACTTCAATGCCTTTAATGGTAGTGCAAAAGGAACAGAAGTCTTGATTCAATCTTCCTTAGAAGCGGATAAGGAAGATATGGCTATCCTATCTCTTCTTTCACGTTATTTCCAAAATCGTGGCATTAAGAAGGTAGATTGGCTCTATAATGCCAACCAAGCAGCAAGTCGTGGATACACCTATCGTTTGGTGGAAATTGCCTTCATTGATAATGAACAAGATATGGCGATTTTTGAAAAGAAGAAAGAGGACATTGCGAAAGGTCTTGTATCAGCAATAACAGGAGTTGAAGTCAAGACAATAGTTCCCTCGCCCCCCAGTTCAACTGTTGGGAGTTCAGGAACTCCTTCAAAACCAATCTATCTTGTTGGTGATAGTCTTAGGGTGTTGCCTCATGCGACTCATTATCAGACTGGTCAGAAAATTGCCAACTGGGTCAAGGGGCGAACCTACAAAATCATCCAAGTGAAGAATGTTCACCAGTCCAACAGTAAGAGAGCTTATCTACTTGATGGAATCAAGTCATGGGTGCTTGAGCAGGATGTAGTAGGAACAACTAAAGGCCATAGTGAGCAGACCTATCAAGCACAGAAAGGCGATACGTATTATGGAATCGCTCGGAAGTTTGGTTTAACAGTTGATGCTCTTCTTGCGATTAATGGCTTGAAGAAGACGGATATTTTAAGAGGTGGACAAACTCTAAAGGTCAATGCGGCTTCAAGGACAACAACCGCTATTCCAACCAGTGTTGCCAGTCGTGTGGTTGCGTCAGCATTATCCAAGGTCGGTCAAAAGGTGACTGTTCCATCTAACCCTTATGGTGGACAGTGTGTTGCCTTGGTGGATAAGATTGTTCAAGAACTTACGGATAAGAATATGTCCTATACTAATGCCATTGATTGTTTGAAGAAAGCAAAATCGAATGGTTTTCAAGTAATCTACGATGCTTGGGGTGTGAATCCTAAAGCAGGTGATTTTTATGTCATTCAGACGGATGGTTTGGTATATGGTCACATTGGTGTCTGTGTGACGGATTCAGACGGAAAAAGTATTGATGGCGTGGAACAGAATATTGATGGATATTCTGACCATAATAAGAACGGTATCAATGACCAATTGGAAATAGGTGGCGGTGGTATCACTCGTCGTGTAAAACGTCAATGGATGGCGGATGGCTCACTCTACGATTCAACTGGAACAGTTAAACTCGGTAAAGTTGTAGGTTGGTTTAGAATTTCATAA

Gene Ontology

Description Category Evidence (source)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0008932 lytic endotransglycosylase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi000378f0af_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (7ctcW) rather than this protein.
PDB ID
7ctcW
Method AlphaFoldv2
Resolution 77.01
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50