Protein

Protein accession
F0PIJ7 [UniProt]
Representative
7zIOC
Source
UniProt (cluster: phalp2_16579)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MTLNVIDISSWQTGINLGKDGVPADGVVIKATGGTGYVNPDCDRAFQEAIKSGKKVAVYHYAHEIGFQGTAEQEAEFFLQNVAGYIGKAILILDWESDNKHDVAWAKRWLDTVYEKTGIKPLFYTYTHMVNNYDFSSIGNADYGLWIANYLSDKPQGYSQPAPPISNGFPLTVMYQYTSSGKLPGWGGYLDLNVFYGTLEDWDLYATGSKRPEKENEEINNNKKEVATMHCIYERPMRDGKPNNDNGNTWGKYYCNGVNCRHIPYEDNVKLLKELYKKNNGHEMPVYTKEDWTIYAPWYKRLEEMFPVV
Physico‐chemical
properties
protein length:309 AA
molecular weight:35265,2 Da
isoelectric point:5,44
hydropathy:-0,60
Representative Protein Details
Accession
7zIOC
Protein name
7zIOC
Sequence length
299 AA
Molecular weight
33921,83490 Da
Isoelectric point
6,30813
Sequence
MTLFGIDISGWQAGINLSAVPTDFVIVKATGGTGYVNPDFKRQANQTLATNKLLGLYHFANDSGYQGTAIAEAEHFVNSVGDYLGKAVLVLDWEAENKANITWAREFLWHVHKLTGVKAWFYTYTFVLNAYDFSVLGNEGWPLWLADYPYSATQHGFAEYKQPSRRGFPYPAIAYQYSSTTILDGYGGHLDVNNFYGTQVDWLNYAKGNKVVAEQPKEKIKEVATMFCTYQEEGGNAIFYFDGKNVTVLAHEDEWQVLKMIYKANNDRDLPHFVFKEKAPFNKRLEHLVKRAVYPSLKA
Other Proteins in cluster: phalp2_16579
Total (incl. this protein): 8 Avg length: 305,8 Avg pI: 6,14
Protein ID Length (AA) pI
7zIOC 299 6,30813
3bWy6 301 9,70522
7BOav 312 5,56695
8pCxd 302 6,09839
8r0zA 308 5,72132
OTz1 323 4,69276
A0A8D6UFI2 292 5,56303
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_37341
8v6XY
 562 42,1% 223 1.119E-71
2 phalp2_24845
7umqo
 6 38,9% 236 3.862E-68
3 phalp2_4660
4CJrS
 5 37,1% 218 1.325E-64
4 phalp2_32821
2L8bh
 41 35,4% 223 8.664E-64
5 phalp2_4274
8cjfF
 9 41,5% 214 8.664E-64
6 phalp2_27394
4HDMm
 9 36,7% 215 2.706E-62
7 phalp2_12276
79roT
 46 40,0% 217 6.917E-62
8 phalp2_20117
23DDy
 70 43,3% 189 2.948E-60
9 phalp2_35154
5HNke
 1 35,8% 290 2.540E-56
10 phalp2_36024
5HOPw
 12 44,2% 217 3.749E-54

Domains

Domains [InterPro]
GH25
Unannotated
Representative sequence (used for alignment): 7zIOC (299 AA)
Member sequence: F0PIJ7 (309 AA)
1 299 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Enterococcus phage EF62phi
[NCBI] 		977801 No lineage information
Host Enterococcus faecalis 62
[NCBI] 		936153 Firmicutes > Bacilli > Lactobacillales > Enterococcaceae > Enterococcus >

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
CP002495 [NCBI]
CDS location
range 16573 -> 17502
strand +
CDS
ATGACATTGAACGTCATTGATATTTCTAGTTGGCAGACAGGTATTAATTTAGGAAAAGATGGTGTTCCTGCTGATGGGGTTGTTATTAAAGCTACAGGAGGAACTGGATATGTTAACCCTGATTGTGATCGAGCATTTCAAGAAGCAATTAAAAGTGGTAAAAAAGTAGCGGTCTATCATTATGCACATGAAATCGGCTTTCAAGGAACAGCTGAACAAGAAGCGGAATTCTTTTTACAAAATGTAGCTGGATATATTGGAAAAGCGATTCTTATCCTAGATTGGGAAAGTGACAATAAACATGATGTAGCATGGGCAAAGCGTTGGTTAGATACTGTTTATGAAAAAACAGGAATTAAACCATTATTTTATACGTATACACACATGGTTAATAATTATGATTTTTCTAGTATTGGAAATGCTGATTATGGGTTATGGATTGCAAATTATCTAAGTGACAAACCACAAGGATATAGTCAACCAGCACCGCCTATCAGTAATGGGTTTCCTTTAACAGTGATGTATCAATATACATCAAGTGGGAAATTACCTGGCTGGGGTGGATACCTGGATTTAAATGTATTTTATGGAACGCTTGAAGACTGGGACTTATATGCAACAGGAAGTAAGCGGCCAGAAAAAGAAAATGAAGAAATAAATAATAATAAAAAGGAAGTGGCAACTATGCATTGTATTTATGAACGACCAATGAGAGATGGAAAACCAAATAATGATAATGGAAACACGTGGGGGAAATATTATTGTAATGGCGTTAATTGCCGTCATATCCCATATGAAGATAACGTTAAGTTATTGAAAGAACTATACAAAAAGAACAATGGACACGAAATGCCTGTTTATACAAAAGAAGACTGGACTATCTATGCGCCGTGGTATAAACGATTAGAAGAAATGTTTCCAGTTGTCTAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
F0PIJ7
Method SMR
Resolution –
Chain position –
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
PDB ID
upi00019f3738_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (7zIOC) rather than this protein.
PDB ID
7zIOC
Method AlphaFoldv2
Resolution 88.67
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50