Protein

Protein accession
Q65YV6 [UniProt]
Representative
5oePU
Source
UniProt (cluster: phalp2_11124)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MVEVAKRSYGVDVSSHNNGNYSGSKFAVVKVSEGLDYRNPKAQSQVSTARANSMLPMAYHYARFSGNSNVAIQEGNYAVTSAKAVGLEAGTYLACDYEQGSGNETRGDRETNTTAILSFLDTIVGAGYKPLLYSGAYLMRDKINTSRILAKYPNCLWVAAYPSGNGTAVSEPNFGYFPSMNGVAIWQFTDNWRGLNVDGNISLIDLKNDSKPVAQPSVAQSASEKTWTDVQGMTWHEEHGTFITGGAINLRWGANTQSTLITTLPAGSEVKYNAWARDSAGRVWLQQPRENGKNGYLVGRVGSEPWGTFK
Physico‐chemical
properties
protein length:310 AA
molecular weight:33701,1 Da
isoelectric point:8,37
hydropathy:-0,42
Representative Protein Details
Accession
5oePU
Protein name
5oePU
Sequence length
360 AA
Molecular weight
38481,47610 Da
Isoelectric point
9,09683
Sequence
MANAYGVDVSSFQPTNMASYANAGAKLAIVKLSEGMDYRNPKATSQIASAKANGMMIAGYFFATFSSNATAANYQAQVAVATARQVKLAKGSYLAVDWETGDGNVVTNSIGNNTQALLSAMASIKLAGYKPLLYAGAYDLKVHVDRASILWTFPNSLWVASYPYQNGVRVDKAPMGSFPSMDGVAIWQFTDNWCGMSVDGNIAVLDLKTGESEADIEMAWHPEVKIGELGRFMVNRQNGASLYGDAALTKVIGTKKYGESFKIFRAKGGAVCAGDSQWFSQADGLTKINPLAVNSWARGICKITVSDAYTQNLPKAGQLGITHLPKGGTYKVFGRSGKYLLVGSEKVGKYVDGDKCVIVL
Other Proteins in cluster: phalp2_11124
Total (incl. this protein): 31 Avg length: 364,9 Avg pI: 7,84
Protein ID Length (AA) pI
5oePU 360 9,09683
5oGMc 358 9,14144
5tTsT 347 8,10956
6AHJd 358 9,05931
6ZcSF 371 6,00444
70ESu 374 6,25351
71Jic 392 9,57486
72b0m 368 9,23518
744bm 368 9,19849
7BOyM 374 6,08060
7BY2p 367 8,04019
7RfLs 367 7,50976
7Rfkw 373 5,43514
7pYTq 369 9,69638
7vQbB 382 9,62579
7vQqL 370 9,47416
8K2tn 367 8,04019
8K2to 367 8,32482
8K2tz 357 6,45250
8LSiO 373 5,53762
8lwh5 357 6,31086
CXYR 373 9,60645
CmEE 373 5,73371
Ono8 371 6,32529
och7 370 9,40099
ufRu 373 9,62934
wuzJ 373 5,78680
ww4b 367 8,04019
B8R665 373 5,53762
X2CXX8 310 8,36543
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_14510
4SuEX
 6 33,0% 381 6.366E-77
2 phalp2_7780
7iNFi
 6 29,6% 344 2.385E-37
3 phalp2_7658
6ucuX
 7 25,9% 377 2.385E-37
4 phalp2_11344
7rGpn
 1 21,7% 367 5.566E-20
5 phalp2_11324
7cdUH
 5 23,8% 289 3.381E-18
6 phalp2_39912
1jXPT
 300 26,9% 226 2.002E-16
7 phalp2_38365
InEX
 1 22,7% 233 2.676E-16
8 phalp2_36883
7sfSC
 39 24,5% 224 3.635E-15
9 phalp2_16579
7zIOC
 8 22,4% 298 2.721E-12
10 phalp2_15937
4K3HO
 13 25,0% 283 3.476E-10

Domains

Domains [InterPro]
GH25
Unannotated
Representative sequence (used for alignment): 5oePU (360 AA)
Member sequence: Q65YV6 (310 AA)
1 360 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183

Taxonomy

  Name Taxonomy ID Lineage
Phage Lactobacillus phage phigaY
[NCBI] 		272757 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
AB177605 [NCBI]
CDS location
range 1882 -> 2814
strand +
CDS
ATGGTTGAAGTAGCTAAAAGAAGTTACGGTGTAGATGTATCAAGTCATAACAACGGCAATTATTCCGGATCGAAATTTGCCGTTGTTAAAGTGTCAGAGGGCTTAGATTATCGTAATCCTAAAGCACAATCTCAAGTATCTACTGCAAGAGCTAATAGTATGTTGCCAATGGCTTATCACTATGCGAGGTTTAGTGGCAATAGTAACGTAGCAATTCAAGAAGGTAACTATGCAGTTACTTCTGCAAAAGCTGTTGGTCTTGAGGCAGGTACTTACTTAGCTTGTGACTATGAACAAGGAAGTGGAAACGAAACTAGAGGAGATCGTGAAACTAATACGACTGCTATCTTATCTTTCTTAGATACTATTGTGGGTGCTGGTTATAAGCCTTTACTATACTCAGGCGCTTATCTTATGAGAGACAAAATTAATACTTCTAGAATTTTAGCCAAGTATCCTAATTGTTTGTGGGTAGCAGCATATCCATCAGGTAATGGTACTGCGGTAAGTGAACCAAACTTTGGCTACTTTCCATCAATGAACGGAGTAGCAATTTGGCAATTTACCGATAACTGGCGTGGGTTAAATGTTGACGGAAACATCAGCTTGATTGATCTAAAAAATGATAGCAAACCAGTAGCTCAGCCATCTGTTGCACAATCAGCATCAGAAAAAACATGGACTGATGTACAAGGTATGACTTGGCATGAAGAACATGGTACTTTCATCACTGGTGGAGCGATTAATCTTCGCTGGGGCGCTAATACGCAAAGCACACTGATTACCACCTTACCAGCAGGTTCAGAAGTTAAATACAATGCTTGGGCTAGAGATAGTGCTGGGCGTGTATGGTTACAGCAACCGAGAGAAAATGGTAAGAATGGCTATTTAGTTGGTCGTGTCGGCAGTGAGCCGTGGGGAACTTTCAAATAA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

PDB ID
upi0000381ff3_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (5oePU) rather than this protein.
PDB ID
5oePU
Method AlphaFoldv2
Resolution 93.51
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50