Protein

Protein accession
A0A3S9U7K1 [UniProt]
Representative
2nrBp
Source
UniProt (cluster: phalp2_10624)
Protein name
Lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MTKQLDDNGVQFTGAWEKFSPVPYYATEAERKRGIQTIGKGHVIKAGERFTSISERQADVLLRQDMSEAINRVNAVAHLSLNQAQFNAMCDLVFNVGPNCIRAGTGTGEALRAGDIATLRKKLPQFRNQTQPDGSLKPELGIYRRAVGRLALFDGKPWQEAEAIGRAVKSL
Physico‐chemical
properties
protein length:171 AA
molecular weight:18843,2 Da
isoelectric point:9,55
hydropathy:-0,43
Representative Protein Details
Accession
2nrBp
Protein name
2nrBp
Sequence length
228 AA
Molecular weight
24974,17440 Da
Isoelectric point
9,78361
Sequence
MNQKIQKLAKLLAHLGHSKEAAEVGFFALAQEVYKIQSGDNPWSLSGGDAKYHQMIMDANPKVNWNKLQIGQEITLPAKPSYPNKGMQPSRSAYDIIKSHEKLKLRAYNDGFGNMTIGYGHVIKKGESFSSISEPKAKQLLVSDATAAAKAIQQLVTSKLNQNQFDGLTSLIFNIGRGNFARSSMLKKLNSGDFQGAAREFVSFNNAGGKENAHLTGRRKTEAALFVS
Other Proteins in cluster: phalp2_10624
Total (incl. this protein): 12 Avg length: 222,5 Avg pI: 7,53
Protein ID Length (AA) pI
2nrBp 228 9,78361
1ieD0 224 5,19766
4BsrJ 245 9,31409
4RANU 176 9,48705
5DdBl 221 5,05369
7Tu3p 248 5,68813
807EF 307 7,68124
8iW4T 150 5,49283
8sZ49 175 7,73626
9GmR 253 6,09180
abH1 272 9,29133
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_32792
2snIK
 45 50,3% 141 8.877E-49
2 phalp2_4451
31DIk
 4919 41,8% 148 2.219E-42
3 phalp2_2632
6RhYr
 14867 46,4% 140 5.677E-42
4 phalp2_33221
5jbqV
 447 45,1% 144 1.062E-41
5 phalp2_28113
7zmZV
 50 44,5% 146 3.321E-40
6 phalp2_6830
8n5Jv
 121 43,6% 158 6.210E-40
7 phalp2_6905
2wnW6
 22 40,5% 148 1.037E-38
8 phalp2_4532
3QBcV
 9 45,0% 142 1.938E-38
9 phalp2_126
5jCCA
 637 41,3% 145 2.649E-38
10 phalp2_13372
4eEzY
 340 37,3% 166 4.414E-37

Domains

Domains [InterPro]
Unannotated
GH24
Representative sequence (used for alignment): 2nrBp (228 AA)
Member sequence: A0A3S9U7K1 (171 AA)
1 228 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF00959

Taxonomy

  Name Taxonomy ID Lineage
Phage Pantoea phage vB_PagS_MED16
[NCBI] 		2499074 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MK095605 [NCBI]
CDS location
range 35782 -> 36297
strand +
CDS
ATGACGAAGCAACTAGACGATAATGGTGTTCAATTCACCGGCGCGTGGGAGAAGTTCAGCCCGGTGCCGTACTACGCAACAGAGGCAGAGCGTAAGCGCGGGATCCAGACCATCGGTAAGGGTCACGTGATCAAGGCTGGCGAGCGGTTCACCTCGATCAGCGAGCGCCAGGCTGACGTCCTGCTGCGCCAGGATATGTCAGAGGCAATTAACCGTGTGAATGCCGTTGCTCACCTGTCGCTGAATCAGGCGCAATTTAACGCGATGTGCGACCTGGTGTTTAACGTGGGGCCAAACTGCATCCGTGCCGGTACAGGCACAGGTGAGGCGCTGCGCGCTGGCGACATCGCCACTTTGCGTAAAAAGCTCCCGCAGTTCCGCAACCAGACCCAGCCTGATGGAAGCCTGAAGCCGGAGCTGGGTATCTACCGTCGTGCTGTGGGTCGCCTGGCGTTGTTTGACGGCAAGCCGTGGCAGGAAGCCGAAGCCATTGGCCGCGCGGTGAAGTCGTTATGA

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)
GO:0030430 host cell cytoplasm cellular component None (UniProt)
GO:0031640 killing of cells of another organism biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		RuleBase:RU003788

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (2nrBp) rather than this protein.
PDB ID
2nrBp
Method AlphaFoldv2
Resolution 92.09
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50