Protein

Protein accession
A0A4Y5FEU1 [UniProt]
Representative
8LseV
Source
UniProt (cluster: phalp2_36983)
Protein name
lysozyme
Lysin probability
100%
PhaLP type
endolysin
Probability: 97% (predicted by ML model)
Protein sequence
MNKSWKNTGYVLLLAVLGVLLGLFLVGQSKANASTVVKPVLDTSEWQGYFTDSQAKALKGETSFMILRVQYGSAREDAVFKHNASLLSKYGEPYGVYSFSRYVSVSDAKNEAKALYNRAPNAKFYANDFEVNSVLSGSPNAATKAWYTEMKKLTKKPVVFYSYRNFQQTYAPTAYKSYDAYWLAGYSSYRPSPYNYALWQNTDKYYSRSLGLSVDHSKIITSVHPVSWWIGSKSARTSSTSKYYSGGLFAGEKVRINSGVTAWDAGNSKRSKVDSTVLHRNYTIKQVKTVTKGHSNQEVLLYYKGQPMGWMLAEHLTAYYSSPKVKAVKVINKKGIATYLGNKKVNTYKKGAVLKVSGYTTRNGIPKFIHKGHTTTFTANKNYVKMVSYTNAKSSSTKRTNKHTYYTIQSGDSFWSISQKYHVSMNGLASKNGLSINSTIYPGQRLLIK
Physico‐chemical
properties
protein length:449 AA
molecular weight:50328,6 Da
isoelectric point:9,94
hydropathy:-0,47
Representative Protein Details
Accession
8LseV
Protein name
8LseV
Sequence length
449 AA
Molecular weight
50328,60250 Da
Isoelectric point
9,93692
Sequence
MNKSWKNTGYVLLLAVLGVLLGLFLVGQSKANASTVVKPVLDTSEWQGYFTDSQAKALKGETSFMILRVQYGSAREDAVFKHNASLLSKYGEPYGVYSFSRYVSVSDAKNEAKALYNRAPNAKFYANDFEVNSVLSGSPNAATKAWYTEMKKLTKKPVVFYSYRNFQQTYAPTAYKSYDAYWLAGYSSYRPSPYNYALWQNTDKYYSRSLGLSVDHSKIITSVHPVSWWIGSKSARTSSTSKYYSGGLFAGEKVRINSGVTAWDAGNSKRSKVDSTVLHRNYTIKQVKTVTKGHSNQEVLLYYKGQPMGWMLAEHLTAYYSSPKVKAVKVINKKGIATYLGNKKVNTYKKGAVLKVSGYTTRNGIPKFIHKGHTTTFTANKNYVKMVSYTNAKSSSTKRTNKHTYYTIQSGDSFWSISQKYHVSMNGLASKNGLSINSTIYPGQRLLIK
Other Proteins in cluster: phalp2_36983
Total (incl. this protein): 77 Avg length: 440,1 Avg pI: 9,63
Protein ID Length (AA) pI
8LseV 449 9,93692
28vkd 493 9,93389
3xQqF 449 9,89424
5oJbv 418 9,40853
5oMFD 331 9,48357
5oMFu 418 9,44773
5oNBY 419 9,22589
5tCy3 473 9,20223
5tIsY 418 9,40853
5tQWV 418 9,27631
5tT4M 418 9,40028
5tWF4 419 9,43367
5tXgm 370 9,69722
6AJlE 418 9,29204
6JmJG 373 9,91500
76Nfz 360 9,81636
78N6s 438 9,80856
78iav 417 9,36721
7Ajg8 467 9,43232
7B4bw 464 9,38171
7dptm 373 9,89121
7eRa0 418 9,32324
7fPkn 405 9,06672
7fiCU 420 9,38822
7fuoT 427 9,63617
7lFbl 381 9,60877
7miK1 441 10,07952
7mtvQ 372 9,59194
7nGmB 438 9,59684
7onXZ 438 9,81339
7sd4X 439 9,68562
7sd5A 438 9,45882
7sg7H 438 9,94143
7shrs 438 9,72224
7tfT5 368 9,90378
7u43s 365 10,13419
7vyHt 372 9,83222
7z6Du 374 9,92576
7z8mi 474 10,04064
7z8so 477 10,05760
7zOEm 461 9,45508
7zOr1 466 9,68942
7zOwK 466 9,63101
7znAP 380 9,62998
88pqO 464 9,79895
8K2vq 442 9,70638
8K2vr 461 9,41943
8K2vs 466 9,70567
8LIWa 485 9,84917
8LIhq 463 9,38320
8LmLM 466 9,66434
8LsaF 493 9,90745
8M2Z0 463 9,39022
8MDE5 466 9,74493
8MkAN 461 9,48138
A0A291I9H5 467 9,43232
Q5ULM6 464 9,38171
A0A2K9VCD7 461 9,45508
A0A2K9VCM3 466 9,68942
A0A3Q8HZL4 466 9,63101
A0A2H4PB98 461 9,41943
A0A2K9VDG6 466 9,70567
A0A2K9V5A4 485 9,84917
A0A1S5RCQ2 463 9,38320
A0A3Q8CA00 466 9,66434
A0A4Y5FEB1 493 9,90745
K4I1Y4 463 9,39022
A0A3S7UPN4 466 9,74493
A0A1I9KK58 461 9,48138
A0A2P0ZKX1 463 9,38320
A0A2Z2E736 464 9,78496
A0A3S7UPH0 466 9,62038
A0A4Y5FF73 420 9,93421
A0A4Y5FFC4 493 9,94246
A0AAE8ZPQ2 493 9,81017
A0AAE9H485 463 9,38320
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_354
72wcG
 31 20,7% 419 2.225E-47
2 phalp2_9283
7cTgF
 101 21,0% 414 4.938E-34
3 phalp2_39679
5kP
 52 20,6% 398 3.598E-30
4 phalp2_22096
5ZSom
 2292 21,1% 425 9.190E-29
5 phalp2_17635
6JmE3
 482 21,1% 458 7.179E-28
6 phalp2_26548
858CP
 728 20,6% 427 7.737E-26
7 phalp2_32213
71T7l
 9 25,5% 435 1.956E-22
8 phalp2_21701
3ifCN
 920 22,2% 323 4.571E-19
9 phalp2_4009
11iJK
 7 19,0% 535 4.486E-18
10 phalp2_10110
c1k0
 16 19,7% 425 7.932E-18

Domains

Domains [InterPro]
Disordered region
GH25
Unannotated
Unannotated
LysM
Representative sequence (used for alignment): 8LseV (449 AA)
Member sequence: A0A4Y5FEU1 (449 AA)
1 449 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01183, PF01476

Taxonomy

  Name Taxonomy ID Lineage
Phage Lactobacillus phage 3-521
[NCBI] 		2510943 Herelleviridae > Watanabevirus > Watanabevirus wv3521
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MK504444 [NCBI]
CDS location
range 83499 -> 84848
strand +
CDS
TTGAATAAAAGCTGGAAAAATACCGGATACGTTTTATTACTCGCTGTTTTAGGAGTACTATTAGGACTGTTTCTAGTAGGGCAGTCAAAAGCTAATGCTTCTACTGTCGTTAAACCAGTTTTGGATACCTCTGAATGGCAAGGATACTTTACAGATAGCCAAGCAAAAGCACTTAAAGGAGAAACTTCCTTTATGATTTTGCGGGTACAGTATGGTTCCGCACGAGAAGATGCAGTCTTTAAACATAATGCATCCTTACTATCTAAATATGGAGAACCTTATGGTGTTTACTCTTTTAGTCGTTACGTTTCTGTAAGCGACGCTAAGAATGAAGCTAAAGCGCTGTATAACAGAGCTCCTAATGCAAAGTTTTATGCAAATGACTTTGAAGTTAACTCAGTACTATCTGGTAGTCCTAATGCAGCTACTAAAGCATGGTATACAGAAATGAAGAAGTTAACCAAAAAGCCTGTTGTATTTTATAGTTACCGCAATTTTCAACAGACCTATGCACCAACAGCTTATAAGAGTTATGATGCCTATTGGCTTGCAGGATACAGTTCTTATCGACCATCACCATATAACTATGCATTATGGCAGAATACAGATAAGTACTATAGTCGTAGCCTAGGATTATCAGTAGACCACTCTAAAATCATTACTAGTGTACATCCTGTAAGCTGGTGGATTGGTAGCAAGAGTGCACGTACTAGTAGTACAAGTAAGTACTACTCTGGTGGACTATTTGCTGGTGAAAAAGTTAGAATTAACTCTGGAGTAACTGCATGGGATGCAGGAAATAGTAAAAGGTCTAAGGTGGATAGTACTGTACTACACCGGAATTATACTATTAAGCAAGTTAAAACAGTTACTAAGGGGCACTCAAACCAGGAAGTTCTTTTGTACTACAAAGGACAACCAATGGGATGGATGCTTGCAGAACATTTAACTGCATACTACTCATCACCTAAAGTTAAAGCTGTTAAGGTGATTAACAAGAAGGGTATTGCAACTTACCTAGGAAATAAAAAGGTTAACACCTATAAAAAGGGTGCTGTTCTTAAGGTAAGTGGCTATACTACTCGTAATGGTATTCCAAAGTTCATTCACAAGGGACATACAACAACATTTACGGCAAATAAAAACTATGTAAAGATGGTAAGTTATACTAATGCTAAGAGTTCTTCTACCAAAAGGACAAACAAGCATACGTATTATACTATTCAGTCAGGGGATTCCTTCTGGTCAATCAGTCAAAAGTACCATGTATCCATGAATGGTTTGGCAAGTAAAAATGGTCTAAGCATAAATAGTACTATTTATCCAGGTCAGCGCTTGCTAATTAAGTAG

Gene Ontology

Description Category Evidence (source)
GO:0003796 lysozyme activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0016052 carbohydrate catabolic process biological process None (UniProt)
GO:0016998 cell wall macromolecule catabolic process biological process None (UniProt)

Enzymatic activity

EC Number Entry Name Reaction Catalyzed Classification Evidence Source
3.2.1.17 None Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins. match to sequence model evidence used in automatic assertion
ECO:ECO:0000256 		ARBA:ARBA00000632

Tertiary structure

No tertiary structures available for this protein.

The structures below correspond to the cluster representative (8LseV) rather than this protein.
PDB ID
8LseV
Method AlphaFoldv2
Resolution 80.50
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50