Protein

Protein accession
A0A222YZS4 [UniProt]
Representative
8JtqS
Source
UniProt (cluster: phalp2_2842)
Protein name
LysM-like peptidoglycan binding protein
Lysin probability
100%
PhaLP type
endolysin
Probability: 99% (predicted by ML model)
Protein sequence
MATPMTATQIVAQLKKWGIKYKEVKSWKTHNRNSVGAWGGMNGFIWHHTGADVTAAKAGEYAGNILYNGISGLPGPLCHFGLAPDGMVYLVGWGRANHAGGGDPTVLNHVINEDYSKQLKPTRGNSNGTDGNAHFYGVEIMYSGSRKMTDAQYKTALKLSAAILDFHKWTEKSVIGHGEWSNDKWDPGYASGKIMDMVKVRADIKATKAAGPGGTTPAPKPTPAPTPTAGTYTVKKGDTLWSVSQAYKVSVADLKSWNGLKSDDLAIGQVLKTKKPATTTPTPPKPPTVPTIPVPVPVIIPKSRETKDTIVAQAAVALKAWPFISEIEKVKGLPTGMLLAVGSRETNLTNVIGDGGHGFGVWQRDNRYWPVDESYLLDVKKQAEDAATLLADNYKVLKSWDYAVAAYNAGVDGVQKALAALKSADAATTGGDYAADVLGRLTFTKDVAPTTTPTPTLEQRVTELEKKVSALEKK
Physico‐chemical
properties
protein length:474 AA
molecular weight:50784,3 Da
isoelectric point:9,30
hydropathy:-0,35
Representative Protein Details
Accession
8JtqS
Protein name
8JtqS
Sequence length
474 AA
Molecular weight
50784,25290 Da
Isoelectric point
9,30042
Sequence
MATPMTATQIVAQLKKWGIKYKEVKSWKTHNRNSVGAWGGMNGFIWHHTGADVTAAKAGEYAGNILYNGISGLPGPLCHFGLAPDGMVYLVGWGRANHAGGGDPTVLNHVINEDYSKQLKPTRGNSNGTDGNAHFYGVEIMYSGSRKMTDAQYKTALKLSAAILDFHKWTEKSVIGHGEWSNDKWDPGYASGKIMDMVKVRADIKATKAAGPGGTTPAPKPTPAPTPTAGTYTVKKGDTLWSVSQAYKVSVADLKSWNGLKSDDLAIGQVLKTKKPATTTPTPPKPPTVPTIPVPVPVIIPKSRETKDTIVAQAAVALKAWPFISEIEKVKGLPTGMLLAVGSRETNLTNVIGDGGHGFGVWQRDNRYWPVDESYLLDVKKQAEDAATLLADNYKVLKSWDYAVAAYNAGVDGVQKALAALKSADAATTGGDYAADVLGRLTFTKDVAPTTTPTPTLEQRVTELEKKVSALEKK
Other Proteins in cluster: phalp2_2842
Total (incl. this protein): 58 Avg length: 407,7 Avg pI: 8,76
Protein ID Length (AA) pI
8JtqS 474 9,30042
13hQN 473 9,08922
1IceM 508 6,17075
3fIbT 508 6,34286
4Ll1i 416 8,28304
6IZDU 520 9,18019
7ANbC 474 9,30867
8JtqT 474 9,14918
8JtqU 473 9,20217
8JtqW 471 9,26567
8JtqX 418 9,19978
8JtqY 474 9,31608
8MIPH 473 9,35618
8MJOQ 471 9,35612
A0A345M7T2 293 8,88827
A0A5Q2WI49 298 8,86616
A0A482JFS3 474 9,30867
A0A4D6E2L4 258 6,74869
A0A5Q2WLK5 338 8,89627
A0A223FZU2 474 9,14918
A0A222YYD3 473 9,20217
A0A222YYH6 471 9,26567
A0A2L1IVJ9 418 9,19978
A0A0A0RQG1 474 9,31608
A0A411AXW9 261 7,82532
A0A345M9R9 339 9,03023
A0A514DK00 473 9,35618
A0A514U1V4 471 9,35612
A0A221SAT9 473 9,39216
A0A222Z0G3 471 9,26567
A0A345MH82 293 8,88827
A0A411B613 474 9,25761
A0A4D6E0V0 416 9,13951
A0A514DET7 312 9,02565
A0A5Q2WIH2 474 9,25761
A0A6G8R1C6 338 6,51161
A0A6G8R301 336 6,51269
A0A6G9LBR5 299 8,38967
A0A7G9UW86 340 7,18339
A0A7G9UYL9 301 9,30068
A0A7G9W1F2 340 7,18339
A0A7L8ZF78 350 9,18702
A0A890UT79 474 9,34780
A0A8F2E6I4 341 8,31186
A0A9E7IIU1 293 8,69622
A0A9E7IQ01 293 8,69622
A0A9X9K3L1 258 7,12786
A0AA49BRQ5 337 9,11784
A0AA49BT34 471 9,26567
A0AA51GI30 338 8,90561
A0AA96H5N4 471 9,26567
A0AA96HEX1 338 8,76262
A0AA96HGG1 474 9,34780
A0AAX4LVL7 476 9,02772
A0AAX4NP49 474 9,34780
A0AAX4RAW8 299 8,67591
A0AAX4RB50 474 9,34780
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_12291
7ggQn
 288 44,5% 296 5.027E-88
2 phalp2_2737
7uk55
 6 30,1% 322 2.410E-26
3 phalp2_24820
7loRH
 2 27,2% 297 9.370E-18

Domains

Domains [InterPro]
Ami2
LysM
Unannotated
Representative sequence (used for alignment): 8JtqS (474 AA)
Member sequence: A0A222YZS4 (474 AA)
1 474 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01476, PF01510

Taxonomy

  Name Taxonomy ID Lineage
Phage Streptomyces phage Peebs
[NCBI] 		2023994 Stanwilliamsviridae > Samistivirus > Samistivirus peebs
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MF347638 [NCBI]
CDS location
range 21409 -> 22833
strand +
CDS
ATGGCAACACCAATGACAGCAACGCAGATTGTTGCTCAGCTCAAGAAGTGGGGAATCAAGTACAAGGAAGTAAAGTCTTGGAAGACCCACAACAGAAACTCTGTCGGTGCTTGGGGTGGAATGAACGGATTTATCTGGCATCACACTGGCGCTGACGTGACCGCTGCCAAGGCTGGAGAATATGCAGGAAACATTCTCTACAATGGTATTTCTGGTCTGCCTGGTCCTCTATGCCACTTTGGTCTAGCACCAGATGGTATGGTTTACCTAGTAGGATGGGGTCGTGCAAATCACGCTGGAGGTGGAGACCCTACGGTTCTCAACCACGTAATCAATGAAGATTACTCCAAACAGCTCAAGCCTACTCGTGGTAATTCAAACGGTACTGATGGTAACGCTCATTTCTATGGCGTGGAAATCATGTATTCCGGAAGTCGCAAGATGACCGATGCTCAGTACAAGACTGCGCTTAAGCTTTCAGCAGCCATTCTAGATTTCCACAAGTGGACTGAAAAGTCTGTAATTGGACACGGTGAATGGTCTAATGACAAGTGGGACCCAGGCTATGCTTCTGGAAAGATTATGGATATGGTGAAGGTTCGTGCCGATATCAAGGCAACGAAGGCAGCCGGACCAGGTGGAACAACTCCTGCTCCAAAGCCAACACCTGCACCTACTCCAACGGCCGGAACGTATACGGTAAAGAAGGGTGACACCCTATGGAGTGTTTCTCAGGCATACAAGGTATCCGTTGCAGACCTAAAGTCTTGGAATGGACTAAAGTCCGACGACCTAGCAATTGGTCAGGTTCTCAAGACAAAGAAGCCTGCTACGACTACCCCAACGCCACCTAAGCCACCAACGGTTCCTACAATTCCAGTGCCAGTGCCAGTAATCATTCCTAAATCTCGTGAGACAAAGGACACTATTGTTGCACAGGCAGCCGTTGCGCTAAAGGCGTGGCCTTTCATCAGCGAAATTGAAAAGGTCAAGGGACTTCCAACAGGGATGCTTCTTGCAGTCGGTTCTCGTGAAACAAACCTCACCAATGTAATTGGCGACGGTGGTCACGGATTTGGAGTTTGGCAGCGTGATAACAGATATTGGCCAGTCGATGAATCATATCTTCTTGATGTGAAGAAGCAGGCCGAAGATGCTGCAACACTCCTTGCTGACAATTACAAGGTTCTAAAGAGTTGGGATTATGCTGTAGCCGCATACAATGCAGGTGTGGATGGGGTTCAGAAGGCTCTAGCCGCTCTAAAATCTGCTGATGCAGCGACTACAGGTGGAGACTATGCAGCAGACGTTCTCGGTAGACTAACCTTTACCAAGGATGTAGCTCCAACAACTACTCCAACCCCAACGCTTGAGCAGCGTGTGACGGAGCTTGAGAAAAAGGTTTCCGCACTTGAAAAGAAGTAA

Gene Ontology

Description Category Evidence (source)
GO:0001897 symbiont-mediated cytolysis of host cell biological process None (UniProt)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0008932 lytic endotransglycosylase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)
GO:0042742 defense response to bacterium biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi000b94a69a_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (8JtqS) rather than this protein.
PDB ID
8JtqS
Method AlphaFoldv2
Resolution 87.06
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50