Protein

Protein accession
A0A4D6A315 [UniProt]
Representative
71Vqv
Source
UniProt (cluster: phalp2_23517)
Protein name
Cell wall hydrolase
Lysin probability
100%
PhaLP type
endolysin
Probability: 98% (predicted by ML model)
Protein sequence
MSKHLVICGHGQGRTAYDPGAINSKRGITEAGKVRELAKLMSKYSGKSIDYITDQNVYDYQSLASLGKGYDSITELHFNAFNVTARGTEVLIQSSLTADQEDEAILTVLAKYFPNRGIKKVDWLYNANVAKERGYTYRLVEIAFIDNEADMTIFETKKEEIAKGLVSAITKQEVTTSTLQPTSQQPNPSTSDSTSVDYPIGGHVRVLPHATHYQTGQAIATWVKGKTYTILQKKTVKQSRSTKAYLLSGINSWVLEQDLEVIQTVHSEQTYRVQKGDTYYGVAKRFGLSLDQLLLVNGLKKTDVLKIGQTLKVHPSSKTITSIPTSVAQRVVASALSKVGQKVTVPTNPYGGQCVSLVDKIVQEVTDKNMAYTNAIDCLTKAKDNGFTVIQDEWGVNPKAGDFYVIDTFGMPYGHIGICISDSDGTSIDGVEQNVDGYSDNNKNGINDQLEIGGGGITRRVKRVWMADGSIYDASGTVKLGKVIGWFRV
Physico‐chemical
properties
protein length:489 AA
molecular weight:53613,0 Da
isoelectric point:8,53
hydropathy:-0,32
Representative Protein Details
Accession
71Vqv
Protein name
71Vqv
Sequence length
489 AA
Molecular weight
53613,01480 Da
Isoelectric point
8,53105
Sequence
MSKHLVICGHGQGRTAYDPGAINSKRGITEAGKVRELAKLMSKYSGKSIDYITDQNVYDYQSLASLGKGYDSITELHFNAFNVTARGTEVLIQSSLTADQEDEAILTVLAKYFPNRGIKKVDWLYNANVAKERGYTYRLVEIAFIDNEADMTIFETKKEEIAKGLVSAITKQEVTTSTLQPTSQQPNPSTSDSTSVDYPIGGHVRVLPHATHYQTGQAIATWVKGKTYTILQKKTVKQSRSTKAYLLSGINSWVLEQDLEVIQTVHSEQTYRVQKGDTYYGVAKRFGLSLDQLLLVNGLKKTDVLKIGQTLKVHPSSKTITSIPTSVAQRVVASALSKVGQKVTVPTNPYGGQCVSLVDKIVQEVTDKNMAYTNAIDCLTKAKDNGFTVIQDEWGVNPKAGDFYVIDTFGMPYGHIGICISDSDGTSIDGVEQNVDGYSDNNKNGINDQLEIGGGGITRRVKRVWMADGSIYDASGTVKLGKVIGWFRV
Other Proteins in cluster: phalp2_23517
Total (incl. this protein): 51 Avg length: 470,5 Avg pI: 8,89
Protein ID Length (AA) pI
71Vqv 489 8,53105
1Rd 485 9,01270
1bNLc 489 8,66863
4QC 489 9,13486
5KySc 489 9,14157
6odM0 489 9,08967
6ulKs 489 9,01244
726lp 489 9,18850
72LFT 489 9,01901
72rR3 489 9,03178
72rS1 489 8,89736
72w9H 489 9,07033
73KqL 489 8,97904
73cVa 489 9,07027
74aLY 489 8,86081
74ePb 489 9,14144
75m7t 489 9,01270
75miz 489 9,07027
75uAL 489 9,20243
75v1t 489 8,94752
75vNA 489 9,08310
75vl1 489 9,13493
75vsz 489 9,14840
75vwu 489 9,08967
75w5C 489 9,10334
7eHIH 489 9,08974
7eIOp 489 9,02514
7gefK 489 9,01889
7gucZ 489 9,07658
7hF6x 489 9,25684
7hc5R 489 8,94771
7hmpv 489 9,08303
7iBHy 489 9,01876
7j22k 489 9,16252
7jmEF 489 8,78519
7jmET 489 9,03829
7jmlS 489 8,95364
7jmto 489 9,24536
7m250 489 9,07658
7m2Fa 489 9,08974
7ocl4 489 8,80930
7ocoL 489 9,08297
7z5fB 489 9,12822
8H3ls 489 8,87267
8H3lt 489 9,23827
8H3lu 489 9,01889
bX 489 9,08310
A0A4D6AN23 172 7,73274
A0A7G3MMN1 179 6,30989
A0A7G3MUK0 179 6,30989
Similar Clusters (pHMM search)
# Cluster # Members Identity (%) Alignment Length E-value
1 phalp2_16536
7ctcW
 54 74,7% 325 2.371E-195
2 phalp2_26068
7j23J
 9 62,5% 312 6.102E-130
3 phalp2_24803
725t1
 19 60,2% 312 3.483E-125
4 phalp2_38400
11B5K
 1 25,9% 481 2.781E-22

Domains

Domains [InterPro]
Ami3
Unannotated
LysM
CHAP
Representative sequence (used for alignment): 71Vqv (489 AA)
Member sequence: A0A4D6A315 (489 AA)
1 489 AA (representative)
Domain positions follow the representative sequence above; the member sequence bar is scaled to the same axis.
Legend: EAD CBD Linker Disordered Unannotated
Pfam accessions: PF01476, PF01520, PF05257

Taxonomy

  Name Taxonomy ID Lineage
Phage Streptococcus phage Javan181
[NCBI] 		2548029 No lineage information
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
CDS Source ID
[NCBI]
CDS Source
MK448695 [NCBI]
CDS location
range 32073 -> 33542
strand +
CDS
ATGAGTAAACATCTAGTCATTTGTGGTCATGGCCAAGGGCGAACAGCTTATGATCCAGGAGCAATTAACAGCAAACGTGGGATAACGGAAGCTGGCAAGGTACGTGAGTTAGCTAAACTCATGTCCAAGTACAGTGGAAAATCGATCGACTATATCACAGATCAAAACGTCTATGATTATCAGTCACTGGCAAGCCTTGGTAAGGGCTATGACTCTATTACCGAACTTCACTTTAATGCCTTTAATGTCACGGCACGAGGGACGGAAGTTCTTATTCAATCCTCTTTGACAGCAGACCAAGAAGATGAAGCTATTTTAACTGTGCTTGCCAAGTATTTCCCGAATCGTGGAATTAAGAAGGTGGACTGGCTCTATAATGCCAACGTGGCCAAAGAAAGAGGCTACACTTATCGCTTAGTGGAGATTGCTTTTATCGATAACGAAGCGGACATGACTATCTTTGAAACTAAGAAGGAGGAGATAGCCAAAGGCTTGGTGTCTGCGATTACGAAACAGGAGGTGACAACAAGCACTCTTCAGCCCACCTCCCAACAACCCAATCCTAGTACCAGTGATTCTACCTCTGTTGACTATCCTATTGGTGGTCATGTGCGGGTTCTTCCTCATGCGACACATTACCAAACAGGGCAGGCGATTGCCACTTGGGTTAAGGGAAAGACTTATACGATTTTACAGAAAAAGACGGTAAAGCAGTCAAGGAGTACGAAAGCTTATCTCTTGTCAGGTATCAATTCTTGGGTCTTGGAACAAGACCTTGAGGTGATTCAAACAGTACATAGTGAACAAACCTATAGGGTTCAAAAAGGGGATACTTACTATGGGGTAGCGAAGCGCTTTGGCTTGTCATTAGATCAATTACTTTTAGTCAATGGTTTGAAGAAGACTGATGTCCTCAAGATTGGTCAAACCTTAAAAGTGCATCCTTCTAGCAAAACAATCACTAGTATCCCAACCAGTGTGGCACAACGTGTGGTTGCTTCAGCCTTATCTAAAGTCGGTCAGAAAGTGACTGTGCCAACCAACCCTTATGGTGGGCAATGTGTCAGTCTAGTGGATAAAATTGTGCAGGAAGTGACTGATAAGAACATGGCTTATACGAATGCCATTGATTGTTTGACTAAGGCAAAGGACAATGGTTTTACAGTTATTCAAGATGAGTGGGGAGTAAACCCAAAAGCTGGAGACTTCTATGTGATTGATACGTTTGGTATGCCTTATGGTCACATCGGTATTTGTATCTCTGATTCCGATGGTACAAGCATTGATGGTGTGGAGCAGAATGTGGATGGCTATTCTGACAACAATAAGAACGGCATCAATGATCAATTGGAAATTGGGGGTGGCGGTATCACACGACGAGTGAAGCGTGTTTGGATGGCAGATGGCTCGATTTATGATGCATCTGGCACCGTCAAACTTGGTAAAGTTATCGGTTGGTTTAGAGTATAA

Gene Ontology

Description Category Evidence (source)
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity molecular function None (UniProt)
GO:0008932 lytic endotransglycosylase activity molecular function None (UniProt)
GO:0009253 peptidoglycan catabolic process biological process None (UniProt)

Enzymatic activity

No enzymatic activity data available.

Tertiary structure

PDB ID
upi000217460b_model
Method AlphaFold3 (non-commercial)
Resolution -
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50
The structures below correspond to the cluster representative (71Vqv) rather than this protein.
PDB ID
71Vqv
Method AlphaFoldv2
Resolution 82.55
Chain position -
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50